Material Safety Data Sheet
Tropisetron hydrochloride
Section 1 - Chemical Product and Company Identification
MSDS Name: Tropisetron hydrochloride
Catalog Numbers: SC-22926

Section 2 - Composition, Information on Ingredients 
CAS#105826-92-4
Chemical Name: Tropisetron hydrochloride
Percent: 98%min
EINECS/ELINCS: N/A

Section 3 - Hazards Identification 
GHS classification
PHYSICAL HAZARDS: Not classified
HEALTH HAZARDS: Acute toxicity (Oral): Category 3
ENVIRONMENTAL HAZARDS: Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols 
Signal word: Danger
Hazard statements
Toxic if swallowed
Precautionary statements:
[Prevention]  Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling.
[Response]  IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth.
[Storage]    Store locked up.
[Disposal]   Dispose of contents/container through a waste management company authorized by the local government. 

Section 4 - First Aid Measures 
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.
Ingestion: Immediately call a POISON CENTER or doctor/physician. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-tight goggles.
Section 5 - Fire Fighting Measures 
Suitable extinguishing media: Dry chemical, foam, water spray, carbon dioxide.
Specific hazards arising from the chemical: Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so.
Special protective
equipment for firefighters: When extinguishing fire, be sure to wear personal protective equipment.

Section 6 - Accidental Release Measures 
Personal precautions, protective equipment and emergency procedures:
Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep people away from and upwind of spill/leak. Entry to non-involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for containment and cleaning up: Sweep dust to collect it into an airtight container, taking care not to disperse it. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

Section 7 - Handling and Storage 
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any incompatibilities
Storage conditions: Keep container tightly closed. Store in a refrigerator. Store locked up. Store away from incompatible materials such as oxidizing agents. Heat-sensitive
Packaging material: Comply with laws.

Section 8 - Exposure Controls, Personal Protection 
Engineering controls:
Install a closed system or local exhaust. Also install safety shower and eye bath.
Control parameters:
Not set up
Personal protective equipment
Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations.
Hand protection: Impervious gloves.
Eye protection: Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

Section 9 - Physical and Chemical Properties 
Physical State: Crystalline powder
Color: White to pale yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available
Viscosity: Not available.
Boiling Point: not available
Freezing/Melting Point: 285°C (dec.)
Autoignition Temperature: Not available
Flash Point: Not available
Decomposition Temperature: Not available
Solubility(ies):
[Water] No data available
[Other solvents] Soluble: Methanol
Specific Gravity/Density: N/A
Molecular Formula: C17H20N2O2•HCl
Molecular Weight: 320.82

Section 10 - Stability and Reactivity 
Chemical stability: Stable under proper conditions.
Possibility of hazardous reactions: No special reactivity has been reported.
Incompatible materials: Oxidizing agents
Hazardous decomposition products: Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride

Section 11 - Toxicological Information 
Acute Toxicity:
orl-rat LD50:265 mg/kg
ivn-rat LD50:31400 ug/kg
Skin corrosion/irritation: No data available
Serious eye damage/irritation: No data available
Germ cell mutagenicity: No data available
Carcinogenicity: IARC =No data available
               NTP =No data available
Reproductive toxicity: No data available
RTECS Number: NL6012520
Section 12 - Ecological Information 
Ecotoxicity: Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative potential(BCF): No data available
Mobility in soil Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law constant(PaM3/mol): No data available

Section 13 - Disposal Considerations 
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance.

Section 14 - Transport Information 
Hazards Class: 6.1: Toxic substance.
UN-No: 2811
Proper shipping name: Toxic solid, organic, n.o.s.
Packing group: III

Section 15 - Regulatory Information 
Law for safety of vessels: Hazardous materials notification, Schedule form No.1 Toxic substance

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.