Material Safety Data Sheet
5-(1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride    

Section 1 - Chemical Product and Company Identification
MSDS Name: 5-(1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride
Catalog Numbers: SC-20087

Section 2 - Composition, Information on Ingredients 
CAS#105628-07-7
Chemical Name: 5-(1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride
Synonyms: Fasudil Hydrochloride 
Percent  99%
EINECS/ELINCS: Not available

Section 3 - Hazards Identification 
3.1 Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
3.2 Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
3.3 Other hazards - none 

Section 4 - First Aid Measures 
4.1 Description of first aid measures
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact: Wash off with soap and plenty of water.
In case of eye contact: Flush eyes with water as a precaution.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water.
4.2 Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
4.3 Indication of any immediate medical attention and special treatment needed
no data available

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapors, mist or gas.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
7.3 Specific end uses
no data available

Section 8 - Exposure Controls, Personal Protection 
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
 
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
 
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 
Physical State: Powder.
Color: White
Odor: Not available.
pH: Not available.
Vapor Pressure: No data reported .  
Viscosity: Not available.
 Boiling Point: No data reported 
Freezing/Melting Point: 248 - 249 °C 
Autoignition Temperature: Not available
 Flash Point: No data reported
 Decomposition Temperature: Not available
Water Solubility: Not available
 Specific Gravity/Density:
Molecular Formula: C14H18ClN3O2S
Molecular Weight: 327.83 

Section 10 - Stability and Reactivity 
10.1 Reactivity: no data available
10.2 Chemical stability: no data available
10.3 Possibility of hazardous reactions: no data available
10.4 Conditions to avoid: no data available
10.5 Incompatible materials: Strong oxidizing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available

Section 11 - Toxicological Information 
11.1 Information on toxicological effects
Acute toxicity: no data available
Skin corrosion/irritation: no data available
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitization: no data available
Germ cell mutagenicity: no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity: no data available
Specific target organ toxicity - single exposure: no data available
Specific target organ toxicity - repeated exposure: no data available
Aspiration hazard: no data available

Potential health effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion: May be harmful if swallowed.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: HM4031166

Section 12 - Ecological Information 
Additional ecological information:
General notes: no data available

Section 13 - Disposal Considerations 
13.1 Waste treatment methods
Product: Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging: Dispose of as unused product.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: -                                    IMDG: -                                                  IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -                                    IMDG: -                                                     IATA: -
14.4 Packaging group
ADR/RID: -                      IMDG: -                                                     IATA: -
14.5 Environmental hazards
ADR/RID: no                   IMDG Marine pollutant: no                       IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information 
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2 Chemical Safety Assessment
no data available

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.