Material Safety Data Sheet
Tazarotene   

Section 1 - Chemical Product and Company Identification
MSDS Name: Tazarotene
Catalog Numbers: SC-19506

Section 2 - Composition, Information on Ingredients 
CAS#118292-40-3
Chemical Name: Tazarotene
Percent: 98%
Identified uses : Laboratory chemicals, Manufacture of substances
EINECS/ELINCS: 423-020-5

Section 3 - Hazards Identification 
3.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Chronic aquatic toxicity (Category 4), H413
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 GHS Label elements, including precautionary statements
Pictogram none
Signal word none
Hazard statement(s)
H413 May cause long lasting harmful effects to aquatic life.
Precautionary statement(s)
P273 Avoid release to the environment.
P501 Dispose of contents/ container to an approved waste disposal plant.
3.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

Section 4 - First Aid Measures 
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
no data available
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available 

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13. 

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

Section 8 - Exposure Controls, Personal Protection 
8.1 Control parameters
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

Section 9 - Physical and Chemical Properties 
Physical State: Solid
Color: Light yellow
Odor: Not available.
pH: Not available.
Vapor Pressure:
Viscosity: Not available.
Boiling Point: Not available.  
Freezing/Melting Point: Melting point/range: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Decomposition Temperature: Not available.
Water Solubility: Not available.
Specific Gravity/Density: Not available.
Molecular Formula: C21H21NO2S
Molecular Weight: 351.46

Section 10 - Stability and Reactivity 
10.1 Reactivity: no data available
10.2 Chemical stability: Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions: no data available
10.4 Conditions to avoid: no data available
10.5 Incompatible materials: Strong oxidizing agents
10.6 Hazardous decomposition products: Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Sulphur oxides
Other decomposition products - no data available
In the event of fire: see section 5
 
Section 11 - Toxicological Information 
11.1 Information on toxicological effects
Acute toxicity:
LDLO Oral - rat - > 2,000 mg/kg
Inhalation: no data available
Dermal: no data available: no data available
Skin corrosion/irritation
Skin - Human: Result: Mild skin irritation (Draize Test)
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitisation: no data available
Germ cell mutagenicity: no data available
 
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Reproductive toxicity: no data available
Specific target organ toxicity - single exposure: no data available
Specific target organ toxicity - repeated exposure: no data available
Aspiration hazard: no data available
Additional Information
RTECS: Not available
 
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Section 12 - Ecological Information 
12.1 Toxicity: no data available
12.2 Persistence and degradability: no data available
12.3 Bioaccumulative potential: no data available
12.4 Mobility in soil: no data available
12.5 Results of PBT and vPvB assessment: PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects: no data available

Section 13 - Disposal Considerations 
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

Section 14 - Transport Information 
DOT (US)           Not dangerous goods
IMDG              Not dangerous goods
IATA               Not dangerous goods

Section 15 - Regulatory Information 
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Acute Health Hazard
                               
Section 16 - Additional Information
Full text of H-Statements referred to under sections 2 and 3.
H413 May cause long lasting harmful effects to aquatic life.
HMIS Rating
Health hazard: 0
Chronic Health Hazard:
Flammability: 0
Physical Hazard 0
NFPA Rating
Health hazard: 0
Fire Hazard: 0
Reactivity Hazard: 0

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.