Material Safety Data Sheet
Tobramycin 
Section 1 - Chemical Product and Company Identification
MSDS Name: Tobramycin 
Catalog Numbers: 86-59788

Section 2 - Composition, Information on Ingredients 
CAS# 32986-56-4
Chemical Name: Tobramycin 
Percent  99%
EINECS/ELINCS: 251-322-5
Hazard Symbols: Xi
Risk Phrases: 36/37/38

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Not available

Potential Health Effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion: May be harmful if swallowed.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.

Section 4 - First Aid Measures 
4.1 Description of first aid measures
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact: Wash off with soap and plenty of water.
In case of eye contact: Flush eyes with water as a precaution.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water.
4.2 Most important symptoms and effects, both acute and delayed
Aminoglycosides are associated with significant nephrotoxicity and/or ototoxicity.

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapors, mist or gas.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
7.3 Specific end uses
no data available

Section 8 - Exposure Controls, Personal Protection 
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment
Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Section 9 - Physical and Chemical Properties 
Physical State: Powder
Color: White
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available
Vapor Density: Not available
Viscosity: Not available.
Boiling Point: Not available
Freezing/Melting Point: 168-179℃
Autoignition Temperature: Not available
Flash Point: No data available
Decomposition Temperature:Not available.
Water Solubility: H2O: 50 mg/mL, clear, faintly yellow
Specific Gravity/Density:
Molecular Formula: C18H37N5O9
Molecular Weight: 467.51

Section 10 - Stability and Reactivity 
Chemical Stability: Not available.
Combustion Products: Not available.
Incompatibilities with Other Materials: Strong oxidizing agents
Hazardous Decomposition Products: Not available.
Hazardous Polymerization: has not been reported.

Section 11 - Toxicological Information 
Acute toxicity: LD50 Subcutaneous - Pig - 676 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Ptosis.
Behavioral:Somnolence (general depressed activity). Respiratory disorder
Skin corrosion/irritation: no data available
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitization: no data available
Germ cell mutagenicity: no data available
Carcinogenicity: IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Signs and Symptoms of Exposure: Aminoglycosides are associated with significant nephrotoxicity and/or ototoxicity.
Additional Information: RTECS: WK2100000

Section 12 - Ecological Information 
Not available

Section 13 - Disposal Considerations 
Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging: Dispose of as unused product.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: -                       IMDG: -                             IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -                         IMDG: -                                IATA: -
14.4 Packaging group
ADR/RID: -                            IMDG: -                                  IATA: -
14.5 Environmental hazards
ADR/RID: no                           IMDG Marine pollutant: no        IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information 
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

European Labeling in Accordance with EC Directives
      Hazard Class:Xi
      Risk Phrases:
 
           R 36/37/38 Irritating to eyes, respiratory system and skin
      Safety Phrases:
           S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
           S 37/39 Wear suitable gloves and eye/face protection

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.