Material Safety Data Sheet
(S)-ETHYL 4-CYANO-3-HYDROXYBUTANOATE

Section 1 - Chemical Product and Company Identification
MSDS Name: (S)-ETHYL 4-CYANO-3-HYDROXYBUTANOATE
Catalog Numbers: 86-49147

Section 2 - Composition, Information on Ingredients 
CAS#312745-91-8
Chemical Name: (S)-ETHYL 4-CYANO-3-HYDROXYBUTANOATE
Percent  97%
EINECS/ELINCS:

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Hazard description:
 Xi Irritant
Information pertaining to particular dangers for man and environment
R 36 Irritating to eyes.
Classification system
HMIS ratings (scale 0-4)
(Hazardous Materials Identification System)
HEALTH 1 Health (acute effects) = 1
FIRE 1 Flammability = 1
REACTIVITY 1 Reactivity = 1

GHS label elements
 Warning
3.3/2A - Causes serious eye irritation.
Response:
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Section 4 - First Aid Measures
After inhalation: Supply fresh air. If required, provide artificial respiration. Keep patient warm. Seek immediate medical advice.
After skin contact: Immediately wash with water and soap and rinse thoroughly. Seek immediate medical advice.
After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing: Seek immediate medical advice.

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
Special hazards caused by the material, its products of combustion or resulting gases:
In case of fire, the following can be released:
Carbon monoxide and carbon dioxide
Nitrogen oxides (NOx)
Hydrogen cyanide (HCN)
Protective equipment:
Wear self-contained respirator.
Wear fully protective impervious suit.

Section 6 - Accidental Release Measures 
Person-related safety precautions:
Wear protective equipment. Keep unprotected persons away.
Ensure adequate ventilation
Measures for environmental protection:
Do not allow material to be released to the environment without proper governmental permits.
Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

Section 7 - Handling and Storage 
Handling
Information for safe handling: Keep container tightly sealed. Store in cool, dry place in tightly closed containers. Ensure good ventilation at the workplace.

Information about protection against explosions and fires: Keep ignition sources away.

Storage
Requirements to be met by storerooms and receptacles: No special requirements.
Information about storage in one common storage facility: Store away from oxidizing agents. Further information about storage conditions:
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers.

Section 8 - Exposure Controls, Personal Protection 
Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.
Components with limit values that require monitoring at the workplace: Not required.
Additional information: No data

Personal protective equipment
General protective and hygienic measures
The usual precautionary measures for handling chemicals should be followed. Keep away from foodstuffs, beverages and feed. Remove all soiled and contaminated clothing immediately.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Breathing equipment: Use suitable respirator when high concentrations are present.
Protection of hands:
Impervious gloves
Check protective gloves prior to each use for their proper condition.
Material of gloves
The selection of suitable gloves not only depends on the material, but also on quality.
Quality will vary from manufacturer to manufacturer.
Eye protection: Safety glasses
Body protection: Protective work clothing.

Section 9 - Physical and Chemical Properties 
Physical State: Liquid
Color: Colorless to slight yellow
Odor: Odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 270°C (518°F)
Freezing/Melting Point: Not determined
Flash point: > 110°C (> 230°F)
Autoignition Temperature: N/A
Flash Point: N/A
Upper exp. Limit: N/A
Lower exp. Limit: N/A
Fire Potential: Flammable liquid and vapor.
Decomposition Temperature:Not available.
Vapor pressure: N/A
Solubility:
Density at 20°C (68°F): 1.114 g/cm³
Molecular Formula: C7H11NO3
Molecular Weight: 157.17

Section 10 - Stability and Reactivity 
Thermal decomposition / conditions to be avoided:
Decomposition will not occur if used and stored according to specifications.
Materials to be avoided: Oxidizing agents
Dangerous reactions:  No dangerous reactions known
Dangerous products of decomposition: Carbon monoxide and carbon dioxide, Nitrogen oxides, Hydrogen cyanide (prussic acid)

Section 11 - Toxicological Information 
Acute toxicity:
Primary irritant effect:
on the skin: May cause irritation
on the eye: Irritating effect.
Sensitization: No sensitizing effects known.
Subacute to chronic toxicity:
Other than potential irritation (see above), no information on illness or injury to humans from acute or chronic exposure to this product is available.
Additional toxicological information: To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.
No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH.

Section 12 - Ecological Information 
General notes: Do not allow material to be released to the environment without proper governmental permits.

Section 13 - Disposal Considerations
Product: Recommendation Consult state, local or national regulations to ensure proper disposal.
Uncleaned packagings: Recommendation: Disposal must be made according to official regulations.
Section 14 - Transport Information 
Not a hazardous material for transportation.
DOT regulations:
Hazard class: None
Land transport ADR/RID  (cross-border)
ADR/RID class: None
Maritime transport IMDG:
IMDG Class: None
Marine pollutant: No
Air transport ICAO-TI and IATA-DGR:
ICAO/IATA Class: None
Transport/Additional information: Not dangerous according to the above specifications.

Section 15 - Regulatory Information 
Product related hazard informations:
Hazard symbols:
Xi Irritant
Risk phrases:
36 Irritating to eyes.
Safety phrases:
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Additional: Use of this product is restricted to research and development only.
Some or all of the components of this product are not listed on the Canadian Domestic Substances List (DSL) or the Canadian Non-Domestic Substances List (NDSL).
Information about limitation of use: For use only by technically qualified individuals.
Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.