Material Safety Data Sheet
Acetazolamide 
Section 1 - Chemical Product and Company Identification
MSDS Name: Acetazolamide
Catalog Numbers: 86-43102

Section 2 - Composition, Information on Ingredients 
CAS#59-66-5
Chemical Name: Acetazolamide
Percent  98%
EINECS/ELINCS: 200-440-5
Hazard Symbols: Xi
Risk Phrases: 36/37/38

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. Irritate to eyes, respiratory system and skin.

Potential Health Effects
Eye: Cause eye irritation.
Skin: Cause skin irritation. May be harmful if absorbed through the skin. May cause sensitization by skin contact.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation: May cause respiratory tract irritation. May be harmful if inhaled.
Chronic: Limited evidence of a carcinogenic effect. 

Section 4 - First Aid Measures 
Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Skin: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Ingestion: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
Inhalation: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
Notes to Physician: Treat symptomatically and supportively

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher.

Section 6 - Accidental Release Measures 
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Section 7 - Handling and Storage 
Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Storage: Store between 15 and 30C (59 and 86F), in a well-closed container, unless otherwise specified by manufacturer.

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes: Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Skin: Wear chemical splash goggles. Wear appropriate protective gloves to prevent  skin exposure.
Clothing: Wear appropriate protective gloves, clothing and goggles.
Respirators: Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Section 9 - Physical and Chemical Properties 
Physical State: powder
Color: white

Odor: Not available.
pH: Not available.
Vapor Pressure:Not available
Viscosity: Not available
Boiling Point: Not available
Freezing/Melting Point: 256-261°C
Autoignition Temperature: Not available
Flash Point: Not available
Decomposition Temperature:Not available
Water Solubility: <0.1 g/100 mL at 22 ºC
Specific Gravity/Density:1.771 g/cm3 (20 C)
Molecular Formula: C4H6N4O3S2
Molecular Weight: 222.25

Section 10 - Stability and Reactivity 
Chemical Stability: Sensitive to light.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials: Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents Flammable gases are formed by mixing materials in this group with alkali metals Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information 
RTECS#:  AC8225000   
CAS# 59-66-5:
LD50/LC50: RTECS:AC8225000
CAS# 59-66-5:
Carcinogenicity:
Acetazolamide ,98% - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information found
Other Studies: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

Section 12 - Ecological Information 
a health hazard

Section 13 - Disposal Considerations 
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - Transport Information 
Shipping Name: not regular
RIDADR: 2811
PackingGroup:III
BRN: 212994

Section 15 - Regulatory Information 
European Labeling in Accordance with EC Directives
      Hazard Class: Xi   
        Risk Phrases:
            R36/37/38: Irritating to eyes, respiratory system and skin
            R61 May cause harm to the unborn child
        Safety Phrases:
            S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
            S36: Wear suitable protective clothing
            S45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
            S53 Avoid exposure - obtain special instruction before use

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.