Material Safety Data Sheet
Ondansetron
Section 1 - Chemical Product and Company Identification
MSDS Name: Ondansetron
Catalog Numbers: 86-42309

Section 2 - Composition, Information on Ingredients 
CAS#99614-02-5
Chemical Name: Ondansetron
Percent  99.0%
EINECS/ELINCS:
Hazard Symbols: T, Xi
Risk Phrases: 61-36/37/38

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Toxic if swallowed.. Irritate to eyes, respiratory system and skin.

Potential Health Effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion: Toxic if swallowed.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.

Section 4 - First Aid Measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact: Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed:
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated., Certain individuals may exhibit hypersensitivity reactions such as:, purpuric skin rash, hives, Itching, Difficulty in breathing, Exposure can cause damage to the:, Constipation., Headache,
flushing, May cause nervous system disturbances.

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas.

Section 6 - Accidental Release Measures 
General Information: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.

Section 7 - Handling and Storage 
Handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal Protective Equipment
Eyes: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection: impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respirators: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 

Physical State: Powder
Color: White
Odor: Not available
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point:: Not available
Melting point: Not available
Autoignition Temperature: Not available
Flash Point: Not available
Explosion Limits: Lower: Not available
Explosion Limits: Upper: Not available
Solubility: Not available
Decomposition Temperature:Not available.
Specific Gravity/Density: Not available
Molecular Formula: C18H20ClN3O
Molecular Weight: 329.82

Section 10 - Stability and Reactivity 
Chemical Stability: not available.
Conditions to Avoid:I Not available
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: no data available
Hazardous Polymerization:Has not been reported.

Section 11 - Toxicological Information
Acute toxicity: LD50 Oral - rat - 94,8 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Other. Behavioral:Tremor.
Behavioral: Convulsions or effect on seizure threshold.
Skin corrosion/irritation: largely based on animal evidence
Serious eye damage/eye irritation: largely based on animal evidence
Respiratory or skin sensitization: Did not cause sensitization on laboratory animals: largely based on animal evidence
Germ cell mutagenicity: no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Reproductive toxicity - rabbit - Oral
Effects on Newborn: Growth statistics (e.g., reduced weight gain).
Reproductive toxicity - rabbit - Oral
Maternal Effects: Other effects. Effects on Newborn: Growth statistics (e.g., reduced weight gain).
Other Studies: The toxicological properties have not been fully investigated.
Additional Information
Repeated dose toxicity - rat - Oral - No observed adverse effect level - 1 mg/kg
RTECS: FE6375500

Section 12 - Ecological Information 
Toxicity
Toxicity to fish static test EC50 - Oncorhynchus mykiss (rainbow trout) - 6,5 mg/l - 96 h
NOEC - Oncorhynchus mykiss (rainbow trout) - 2,6 mg/l - 96 h
Toxicity to daphnia and other aquatic invertebrates:
static test EC50 - Daphnia - 28 mg/l - 48 h
static test NOEC - Daphnia - 16 mg/l - 48 h
Toxicity to algae: IC50 - Algae - 0,87 mg/l - 72 h
NOEC - Algae - 0,31 mg/l - 72 h
Toxicity to bacteria IC50 - other microorganisms - > 1.000 mg/l - 3 h
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 18,9 % - Not readily biodegradable.
Method: OECD Test Guideline 301

Section 13 - Disposal Considerations 
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
WGK Germany: 3

Section 14 - Transport Information 
UN number
ADR/RID: 2811                           IMDG: 2811                               IATA: 2811
UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Ondansetron hydrochloride dihydrate)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Ondansetron hydrochloride dihydrate)
IATA: Toxic solid, organic, n.o.s. (Ondansetron hydrochloride dihydrate)
Transport hazard class(es)
ADR/RID: 6.1                             IMDG: 6.1                                    IATA: 6.1
Packaging group
ADR/RID: III                               IMDG: III                                      IATA: III
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no

Section 15 - Regulatory Information 
European/International Regulations
      European Labeling in Accordance with EC Directives
           Hazard Symbols: Xi, T
           Risk Phrases:
                  R25 Toxic if swallowed.
                  R36/37/38 Irritating to eyes, respiratory system and skin.
           Safety Phrases:
                  S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice                 
                  S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
                  S45 In case of accident or if you feel unwell, seek medical advice immediately(show the label where possible).
                          
Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.