Material Safety Data Sheet
2,2,6,6-Tetramethyl-4-piperidinol   
 
Section 1 - Chemical Product and Company Identification
MSDS Name: 2,2,6,6-Tetramethyl-4-piperidinol
Catalog Numbers: 86-37623

Section 2 - Composition, Information on Ingredients 
CAS#603-33-8
Chemical Name:  2,2,6,6-Tetramethyl-4-piperidinol 
Percent  99%
EINECS/ELINCS: 219-291-2

Section 3 - Hazards Identification 
3.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin corrosion (Category 1B), H314
Skin sensitisation (Category 1), H317
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
C Corrosive R34, R43
For the full text of the R-phrases mentioned in this Section, see Section 16.
3.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram 
Signal word Danger
Hazard statement(s)
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard Statements: none
3.3 Other hazards - none

Section 4 - First Aid Measures 
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. 
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
7.3 Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

Section 8 - Exposure Controls, Personal Protection 
8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
 
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

Section 9 - Physical and Chemical Properties 
9.1 Information on basic physical and chemical properties
a) Appearance: Form: Fine crystals with lumps
                        Colour: beige
b) Odour: no data available
c) Odour Threshold: no data available
d) pH: no data available
e) Melting point/freezing point: Melting point/range: 128 - 130 °C
f) Initial boiling point and boiling range: 212 - 215 °C at 1.013 hPa
g) Flash point: no data available
h) Evapouration rate: no data available
i) Flammability (solid, gas): no data available
j) Upper/lower flammability or explosive limits: no data available
k) Vapour pressure: no data available
l) Vapour density: no data available
m) Relative density: 1,09 g/cm3 at 20 °C
n) Water solubility: 149 g/l at 20 °C
o) Partition coefficient: n-octanol/water: no data available
p) Auto-ignition temperature: no data available
q) Decomposition temperature: no data available
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
9.2 Other safety information
      Bulk density 730 kg/m3 at 20 °C
      Solubility in other solvents: Methanol 100 g/l

Section 10 - Stability and Reactivity 
10.1 Reactivity: no data available
10.2 Chemical stability: Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions: no data available
10.4 Conditions to avoid: no data available
10.5 Incompatible materials: Acids, Acid chlorides, Acid anhydrides, Oxidizing agents
10.6 Hazardous decomposition products: Other decomposition products - no data available
In the event of fire: see section 5 

Section 11 - Toxicological Information 
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 2.413 mg/kg
(OECD Test Guideline 401)
LD50 Dermal - rat - > 2.000 mg/kg
(OECD Test Guideline 402)
 
Skin corrosion/irritation
Skin - rabbit
Result: Severe skin irritation
(OECD Test Guideline 404)
 
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitisation
Maximisation Test - guinea pig
Result: Causes sensitisation.
May cause sensitisation by skin contact.
(OECD Test Guideline 406)
 
Germ cell mutagenicity
Ames test
S. typhimurium
Result: negative
 
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure: no data available
Specific target organ toxicity - repeated exposure: no data available
Aspiration hazard: no data available
Additional Information
RTECS: Not available
 
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin.

Section 12 - Ecological Information 
12.1 Toxicity
 
Toxicity to fish static test LC50 - Danio rerio (zebra fish) - > 1.000 mg/l - 96 h
(Directive 67/548/EEC, Annex V, C.1.)
 
Toxicity to daphnia and other aquatic invertebrates
EC50 - Daphnia magna (Water flea) - 560 mg/l - 24 h
(Directive 67/548/EEC, Annex V, C.2.)
 
Toxicity to algae Growth inhibition EC50 - Desmodesmus subspicatus (green algae) - 158 mg/l - 72 h
(Directive 67/548/EEC, Annex V, C.3.)
 
Growth inhibition NOEC - Desmodesmus subspicatus (green algae) - 10 mg/l - 72 h
(Directive 67/548/EEC, Annex V, C.3.)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d Result: 3 % - Not readily biodegradable.
 (Modified Sturm Test)
12.3 Bioaccumulative potential: no data available
12.4 Mobility in soil: no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects: no data available

Section 13 - Disposal Considerations
13.1 Waste treatment methods
Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: 3259                                         IMDG: 3259                                         IATA: 3259
14.2 UN proper shipping name
ADR/RID: AMINES, SOLID, CORROSIVE, N.O.S. (2,2,6,6-Tetramethylpiperidin-4-ol)
IMDG: AMINES, SOLID, CORROSIVE, N.O.S. (2,2,6,6-Tetramethylpiperidin-4-ol)
IATA: Amines, solid, corrosive, n.o.s. (2,2,6,6-Tetramethylpiperidin-4-ol)
14.3 Transport hazard class(es)
ADR/RID: 8                                               IMDG: 8                                                IATA: 8
14.4 Packaging group
ADR/RID: III                                              IMDG: III                                               IATA: III
14.5 Environmental hazards
ADR/RID: no                                             IMDG Marine pollutant: no                   IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out.

Section 16 - Additional Information
Full text of H-Statements referred to under sections 2 and 3.
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
Skin Corr. Skin corrosion
Skin Sens. Skin sensitisation
Full text of R-phrases referred to under sections 2 and 3
C Corrosive
R34 Causes burns.
R43 May cause sensitisation by skin contact.

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.