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Chlorpromazine hydrochloride

Material Safety Data Sheet
Chlorpromazine hydrochloride
Section 1 - Chemical Product and Company Identification
MSDS Name:Chlorpromazine hydrochloride
Catalog Numbers: 86-35162

Section 2 - Composition, Information on Ingredients 
CAS# 69-09-0
Chemical Name: Chlorpromazine hydrochloride
Percent  95%min
EINECS/ELINCS: 200-701-3
Hazard Codes:T+
Risk Phrases: 25-26

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. Irritate to eyes, respiratory system and skin.

Potential Health Effects
Inhalation: May be fatal if inhaled. May cause respiratory tract irritation.
Ingestion: Toxic if swallowed.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation. 

Section 4 - First Aid Measures 
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of soap and water.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - Accidental Release Measures 
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Do not let this chemical enter the environment.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas. Moisture sensitive.
7.3 Specific end uses
no data available
Storage Temp: -20°C Freezer

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 
Physical State: crystalline powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available

Viscosity: Not available.
Boiling Point: Not available
Freezing/Melting Point: 192-196°C
Autoignition Temperature: Not available
Flash Point: Not available
Decomposition Temperature: Not available
Water Solubility: Not available
Specific Gravity/Density: Not available
Molecular Formula: C17H20Cl2N2S
Molecular Weight: 355.33

Section 10 - Stability and Reactivity 
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information 
RTECS#: SO1750000
Acute toxicity
LD50 Oral - rat - 145 mg/kg
LC50 Inhalation - rat - 2 h - 40 mg/m3
CAS#69-09-0:
Carcinogenicity:
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC
Epidemiology: No information found
Other Studies: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

Section 12 - Ecological Information 
a health hazard

Section 13 - Disposal Considerations 
Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging: Dispose of as unused product.
WGK Germany : 3
PackingGroup: III

Section 14 - Transport Information 
14.1 UN number
ADR/RID: 2811                    IMDG: 2811                 IATA: 2811
14.2 UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Chlorpromazine hydrochloride)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Chlorpromazine hydrochloride)
IATA: Toxic solid, organic, n.o.s. (Chlorpromazine hydrochloride)
Passenger Aircraft: Not permitted for transport
14.3 Transport hazard class(es)
ADR/RID: 6.1                      IMDG: 6.1                  IATA: 6.1
14.4 Packaging group
ADR/RID: I                          IMDG: I                      IATA: I
14.5 Environmental hazards
ADR/RID: no                       IMDG Marine pollutant: no             IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information 
European Labeling in Accordance with EC Directives
      Hazard Class: T+
        Risk Phrases:
            R25: Toxic if swallowed
            R26: Very Toxic by inhalation
       Safety Phrases:
            S28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)         
            S36/37: Wear suitable protective clothing and gloves
            S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)  
       FLUKA BRAND F CODES:
            F3: Hygroscopic
            F10: Keep under argon.
            F21: Sensitive to humidity.

Section 16 - Additional Information


While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.