Material Safety Data Sheet
Pirfenidone  
Section 1 - Chemical Product and Company Identification
MSDS Name: Pirfenidone
Catalog Numbers: 86-21600

Section 2 - Composition, Information on Ingredients 
CAS# 53179-13-8
Chemical Name: Pirfenidone  
Percent  99%
EINECS/ELINCS:Not available.

Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 4)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Signal word: Warning
Hazard statement(s): H302 Harmful if swallowed.
Precautionary statement(s): none
Supplemental Hazard Statements: none
Safety data sheet available on request.

Hazard Symbols:Xn
Risk Phrases: 22

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
May cause irritation to eyes, respiratory system and skin.

Potential Health Effects
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion: Harmful if swallowed.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Eyes: May cause eye irritation.

Section 4 - First Aid Measures
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact: Wash off with soap and plenty of water. Consult a physician.
In case of eye contact: Flush eyes with water as a precaution.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
4.3 Indication of any immediate medical attention and special treatment needed: no data available

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx)
5.3 Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information: no data available

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
6.2 Environmental precautions: Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections: For disposal see section 13.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire  protection.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
7.3 Specific end uses: no data available

Section 8 - Exposure Controls, Personal Protection 
8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards  such as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 
Physical State: Solid
Color: Off-white to slight yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.  
Viscosity: Not available.
Boiling Point: Not available. 
Melting point: Not available. 
Autoignition Temperature: Not available
Flash Point: Not available.  
Explosion Limits: Lower: Not available
Explosion Limits: Upper: Not available
Decomposition Temperature: Not available. 
Specific Gravity/Density: Not available.
Molecular Formula: C12H11NO
Molecular Weight: 185.22

Section 10 - Stability and Reactivity 
10.1 Reactivity: no data available
10.2 Chemical stability: no data available
10.3 Possibility of hazardous reactions: no data available
10.4 Conditions to avoid: no data available
10.5 Incompatible materials: Strong oxidizing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available

Section 11 - Toxicological Information
Acute toxicity
LD50 Oral - rat - 1.295 mg/kg
LD50 Oral - mouse - 580 mg/kg
Skin corrosion/irritation: no data available
Serious eye damage/eye irritation: no data available
Respiratory or skin sensitization: no data available
Germ cell mutagenicity: no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information

Section 12 - Ecological Information 
12.1 Toxicity: no data available
12.2 Persistence and degradability: no data available
12.3 Bioaccumulative potential: no data available
12.4 Mobility in soil: no data available
12.5 Results of PBT and vPvB assessment: no data available
12.6 Other adverse effects: no data available

Section 13 - Disposal Considerations 
13.1 Waste treatment methods
Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging: Dispose of as unused product

Section 14 - Transport Information 
14.1 UN number
ADR/RID:  -                                                        IMDG:  -                                                                IATA:  -
14.2 UN proper shipping name
ADR/RID:  Not dangerous goods
IMDG:  Not dangerous goods
IATA:  Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID:  -                                                        IMDG:  -                                                                IATA:  -
14.4 Packaging group
ADR/RID:  -                                                        IMDG:  -                                                                IATA:  -
14.5 Environmental hazards
ADR/RID: no                                                      IMDG Marine pollutant: no                                    IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information 
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

European/International Regulations
           Hazard Symbols: Xn
           Risk Phrases:
                   R22 Harmful if swallowed.
           Safety Phrases:
                   S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
                   S36: Wear suitable protective clothing

 Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.