Material Safety Data Sheet
Phenytoin Sodium 

Section 1 - Chemical Product and Company Identification
MSDS Name: Phenytoin Sodium
Catalog Numbers: 86-07363

Section 2 - Composition, Information on Ingredients 
CAS#630-93-3
Chemical Name: Phenytoin Sodium  
Percent  99%
EINECS/ELINCS: 211-148-2
Hazard Symbols: Xn
Risk Phrases: 22-43-62-63

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. May be harmful if absorbed through skin.

Potential Health Effects
Eye: May cause eye irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Ingestion: Harmful if swallowed.
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Chronic: No information found.

Section 4 - First Aid Measures 
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

Eyes: In case of eye contact,Flush eyes with water as a precaution.
Skin: In case of skin contact,Wash off with soap and plenty of water. Consult a physician.
Ingestion: If swallowed,Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Inhalation: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures 
General Information: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self contained breathing apparatus for fire fighting if necessary.

Section 6 - Accidental Release Measures 
Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections: For disposal see section 13.

Section 7 - Handling and Storage 
Precautions for safe handling: Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Conditions for safe storage, including any incompatibilities:
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Immersion protection. If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection:Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such

as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 
Physical State: Powder
Color: White
Odor: Not available
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available
Freezing/Melting Point: > 300 °C
Autoignition Temperature: Not available
Water solubility: Not available.
Flash Point: Not available
Decomposition Temperature: Not available.
Specific Gravity/Density: Not available.
Molecular Formula: C15H11N2NaO2
Molecular Weight: 274.25

Section 10 - Stability and Reactivity 
Chemical Stability: no data available.
Conditions to Avoid: Avoid moisture. Light.
Incompatible materials: Water
Hazardous Decomposition Products: Other decomposition products - no data available.
Hazardous Polymerization: has not been reported.

Section 11 - Toxicological Information 
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 1.530 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
May cause sensitization by skin contact.
Germ cell mutagenicity
no data available
Carcinogenicity
This product is or contains a component that has been reported to be possibly carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.

IARC: 2B - Group 2B: Possibly carcinogenic to humans (Phenytoin sodium)
2B - Group 2B: Possibly carcinogenic to humans (Phenytoin sodium)

Reproductive toxicity: Possible risk of congenital malformation in the fetus. Suspected human reproductive toxicant Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Signs and Symptoms of Exposure
Gastrointestinal disturbance, Nausea, Dizziness, Headache, Ataxia., Blurred vision, Confusion., Hallucinations., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Additional Information
RTECS: MU1400000

Section 12 - Ecological Information 
12.1 Toxicity
no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
no data available
12.6 Other adverse effects
no data available

Section 13 - Disposal Considerations
Waste treatment methods

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of
this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging: Dispose of as unused product.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: 2811               IMDG: 2811                                   IATA: 2811
14.2 UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Phenytoin sodium)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Phenytoin sodium)
IATA: Toxic solid, organic, n.o.s. (Phenytoin sodium)
14.3 Transport hazard class(es)
ADR/RID: 6.1                 IMDG: 6.1                                        IATA: 6.1
14.4 Packaging group
ADR/RID: III                   IMDG: III                                           IATA: III
14.5 Environmental hazards
ADR/RID: no                 IMDG Marine pollutant: no                IATA: no

14.6 Special precautions for user
no data available

Section 15 - Regulatory Information
European/International Regulations
      European Labeling in Accordance with EC Directives
           Hazard Symbols: Xn
           Risk Phrases:
                   R22: Harmful if swallowed
                   R43: May cause sensitization by skin contact
                   R62: Possible risk of impaired fertility
                   R63: Possible risk of harm to the unborn child
           Safety Phrases:
                  S22: Do not breathe dust
                  S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
                  S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.