Material Safety Data Sheet
Tolvaptan

Section 1 - Chemical Product and Company Identification
MSDS Name: Tolvaptan
Catalog Numbers: SC-20709

 

Section 2 - Composition, Information on Ingredients
CAS#150683-30-0
Chemical Name: Tolvaptan
Percent 99%
EINECS/ELINCS: Not available.
Hazard Symbols: Not available.
Risk Phrases: Not available.

 

Section 3 - Hazards Identification
EMERGENCY OVERVIEW
May be harmful if absorbed through skin. May cause skin irritation.

Potential Health Effects
Eye: May cause eye irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Ingestion: May be harmful if swallowed.
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Chronic: No information found.

 

Section 4 - First Aid Measures
Eyes:In case of eye contact,Flush eyes with water as a precaution.
Skin: In case of skin contact,Wash off with soap and plenty of water.
Ingestion: If swallowed,Never give anything by mouth to an unconscious person. Rinse mouth with water.
Inhalation: If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Notes to Physician: Treat symptomatically and supportively.

 

Section 5 - Fire Fighting Measures
General Information: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Wear self contained breathing apparatus for fire fighting if necessary.

 

Section 6 - Accidental Release Measures
Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections: For disposal see section 13

 

Section 7 - Handling and Storage
Precautions for safe handling: Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Conditions for safe storage, including any incompatibilities: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C

 

Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skincontact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respirators: Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

 

Section 9 - Physical and Chemical Properties
Physical State: Crystalline powder.
Color: White.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 594.4 °C at 760 mmHg.

 Freezing/Melting Point: 219-222°C.
Autoignition Temperature: Not available.
Flash Point: 313.3 °C.
Decomposition Temperature: Not available.
Specific Gravity/Density: 1.311 g/cm3.
Molecular Formula: C26H25ClN2O3.
Molecular Weight: 448.94.

 

Section 10 - Stability and Reactivity
Chemical Stability: Not available.
Conditions to Avoid: Not available.
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products: Not available.
Hazardous Polymerization: has not been reported.

 

Section 11 - Toxicological Information
11.1 Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
RTECS#: Not available.
CAS#150683-30-0
LD50/LC50: RTECS: Not available.
Carcinogenicity:IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Tolvaptan,99%- Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other Studies: The toxicological properties have not been fully investigated.

 

Section 12 - Ecological Information
12.1 Toxicity
no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
no data available
12.6 Other adverse effects
no data available

 

Section 13 - Disposal Considerations
13.1 Waste treatment methods
Product: Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging: Dispose of as unused product.

 

Section 14 - Transport Information
14.1 UN number
ADR/RID: -    IMDG: -     IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -        IMDG: -       IATA: -
14.4 Packaging group
ADR/RID: -    IMDG: -          IATA: -
14.5 Environmental hazards
ADR/RID: no     IMDG Marine Pollutant: no    IATA: no
14.6 Special precautions for user
no data available

 

Section 15 - Regulatory Information
European/International Regulations
European Labeling in Accordance with EC Directives

        Hazard Symbols: Not available.
                Risk Phrases:
                    Not reported
               Safety Phrases:
                    Not reported

 

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.