Material Safety Data Sheet
Trifluoroacetic anhydride
Section 1 - Chemical Product and Company Identification
MSDS Name: Trifluoroacetic anhydride
Catalog Numbers: SC-14194
Section 2 - Composition, Information on Ingredients
CAS#407-25-0
Chemical Name: Trifluoroacetic anhydride
Percent 98%
EINECS/ELINCS: 206-982-9.
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Inhalation (Category 4), H332
Skin corrosion (Category 1A), H314
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram: 
Signal word Danger
Hazard statement(s)
H314 Causes severe skin burns and eye damage.
H332 Harmful if inhaled.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard information (EU)
EUH014 Reacts violently with water.
2.3 Other hazards - none
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye: Causes severe burns.
Skin: May be harmful if absorbed through skin. Causes skin irritation.
Ingestion: May be harmful if swallowed.
Inhalation: May be harmful if inhaled. Causes respiratory tract irritation.
Chronic: No information found.
Section 4 - First Aid Measures
4.1 Description of first aid measures
General advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact: Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.
In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed: Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed: no data available
Section 5 - Fire Fighting Measures
5.1 Extinguishing media
Suitable extinguishing media: Dry powder
5.2 Special hazards arising from the substance or mixture: Carbon oxides, Hydrogen fluoride
5.3 Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information: no data available
Section 6 - Accidental Release Measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Do not flush with water. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
Section 7 - Handling and Storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Never allow product to get in contact with water during storage. Hygroscopic. Store under inert gas.
7.3 Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated
Section 8 - Exposure Controls, Personal Protection
8.1 Control parameters: Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal Protective Equipment
Personal protective equipment
Eye/face protection: Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection: Complete suit protecting against chemicals, Flame retardant protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Color: Colorless.
Odor: Not available.
pH: Not available.
Vapor Pressure: 432,9 hPa at 20 °C
1.831,4 hPa at 55 °C
Viscosity: Not available.
Initial Boiling Point:
Freezing/Melting Point: -65 °C - lit.
Autoignition Temperature: Not available.
Flash Point: Not available.
Decomposition Temperature: Not available.
Specific Gravity/Density: 1,511 g/cm3 at 20 °C.
Molecular Formula: C4F6O3 .
Molecular Weight: 210.03 .
Section 10 - Stability and Reactivity
10.1 Reactivity: no data available
10.2 Chemical stability: Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions: Reacts violently with water.
10.4 Conditions to avoid: Exposure to moisture.
10.5 Incompatible materials: Strong oxidizing agents, Strong acids, Strong bases, Alcohols
10.6 Hazardous decomposition products: Other decomposition products - no data available
In the event of fire: see section 5
Section 11 - Toxicological Information
Acute toxicity: no data available
Inhalation: no data available
Skin corrosion/irritation
Skin - rabbit
Result: Severe skin irritation - 24 h
Serious eye damage/eye irritation
Eyes - rabbit
Result: Severe eye irritation - 24 h
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Additional Information
RTECS: AJ9800000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin, Cough, Shortness of breath, Headache, Nausea
Section 12 - Ecological Information
12.1 Toxicity: no data available
12.2 Persistence and degradability: no data available
12.3 Bioaccumulative potential: no data available
12.4 Mobility in soil: no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
Harmful to aquatic life: no data available
Section 13 - Disposal Considerations
13.1 Waste treatment methods
Product: Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging: Dispose of as unused product.
Section 14 - Transport Information
14.1 UN number
ADR/RID: 3265 IMDG: 3265 IATA: 3265
14.2 UN proper shipping name
ADR/RID: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Trifluoroacetic anhydride)
IMDG: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (Trifluoroacetic anhydride)
IATA: Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
14.3 Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4 Packaging group
ADR/RID: I IMDG: I IATA: I
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
no data available
Section 15 - Regulatory Information
European/International Regulations
Classification according to EU Directives 67/548/EEC or 1999/45/EC
C Corrosive R14, R20, R35, R52/53
For the full text of the R-phrases mentioned in this Section, see Section 16.
Risk Phrases:
R14: Reacts violently with water.
R20: Harmful by inhalation.
R25: Causes severe burns.
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Phrases:
S23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Section 16 - Additional Information
Full text of H-Statements referred to under sections 2 and 3.
Acute Tox. Acute toxicity
Aquatic Chronic Chronic aquatic toxicity
EUH014 Reacts violently with water.
H314 Causes severe skin burns and eye damage.
H332 Harmful if inhaled.
H412 Harmful to aquatic life with long lasting effects.
Skin Corr. Skin corrosion
Full text of R-phrases referred to under sections 2 and 3
C Corrosive
R14 Reacts violently with water.
R20 Harmful by inhalation.
R35 Causes severe burns.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.
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