Material Safety Data Sheet

NIMESULIDE

 

Section 1 - Chemical Product and Company Identification

MSDS Name: NIMESULIDE

Catalog Numbers: SC-17925

 

Section 2 - Composition, Information on Ingredients 

CAS# 51803-78-2

Chemical Name: NIMESULIDE

Percent  98%

EINECS/ELINCS: 257-431-4.

 

Section 3 - Hazards Identification 

3.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 3), H301

For the full text of the H-Statements mentioned in this Section, see Section 16.

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Xn                    Harmful                     R22

For the full text of the R-phrases mentioned in this Section, see Section 16.

3.2 Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram                      

Signal word                   Danger

Hazard statement(s)

H301                  Toxic if swallowed.  

Precautionary statement(s)

P301 + P310            IF SWALLOWED: Immediately call a POISON CENTER or doctor/ Physician.

Supplemental Hazard Statements      none

3.3 Other hazards - none

 

Section 4 - First Aid Measures

4.1 Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician

 

Section 5 - Fire Fighting Measures 

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides

5.3 Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary

5.4 Further information

no data available

 

Section 6 - Accidental Release Measures 

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

Section 7 - Handling and Storage 

7.1 Precautions for safe handling

Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature: 2 - 8 °C  

 

Section 8 - Exposure Controls, Personal Protection 

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.

Personal protective equipment

Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection

Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

 

Section 9 - Physical and Chemical Properties 

Physical State: Solid
Color: Pale yellow
Odor: Not available.

pH: Not available.

Vapor Pressure: Not available.

Viscosity: Not available.

Boiling Point: Not available.
Melting point: Not available.
Autoignition Temperature: Not available

Flash Point: Not available

Explosion Limits: Not available.

Explosion Limits: Not available.

Decomposition Temperature: Not available.

Specific Gravity/Density: Not available

Molecular Formula: C13H12N2O5S

Molecular Weight: 308.31

 

Section 10 - Stability and Reactivity 

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available  

10.6 Hazardous decomposition products

Other decomposition products - no data available

In the event of fire: see section 5

 

Section 11 - Toxicological Information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - rat - 200 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitisation

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Reproductive toxicity - Human - female - Oral

Maternal Effects: Other effects. Effects on Embryo or Fetus: Other effects to embryo. Effects on Newborn:

Physical.

Reproductive toxicity - Human - female - Oral

Effects on Newborn: Physical. Effects on Newborn: Other postnatal measures or effects.  

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Additional Information

RTECS: PB0970000

 

Section 12 - Ecological Information 

12.1 Toxicity

no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

no data available

12.6 Other adverse effects

no data available

 

Section 13 - Disposal Considerations 

13.1 Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

 

Section 14 - Transport Information 

14.1 UN number

ADR/RID: 2811                     IMDG: 2811                                            IATA: 2811

14.2 UN proper shipping name

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Nimesulide)

IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Nimesulide)

IATA: Toxic solid, organic, n.o.s. (Nimesulide)

14.3 Transport hazard class(es)

ADR/RID: 6.1                    IMDG: 6.1                                           IATA: 6.1

14.4 Packaging group

ADR/RID: III                    IMDG: III                                              IATA: III  

14.5 Environmental hazards

ADR/RID: no                  IMDG Marine pollutant: no                IATA: no

14.6 Special precautions for user

no data available

 

Section 15 - Regulatory Information 

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out                              

 

Section 16 - Additional Information

Full text of H-Statements referred to under sections 2 and 3.

Acute Tox.              Acute toxicity

H301                      Toxic if swallowed.

Full text of R-phrases referred to under sections 2 and 3

Xn                   Harmful

R22                 Harmful if swallowed.

 

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.