Material Safety Data Sheet
Sitagliptin 
Section 1 - Chemical Product and Company Identification
MSDS Name: Sitagliptin 
Catalog Numbers: 86-41798

Section 2 - Composition, Information on Ingredients 
CAS# 486460-32-6
Chemical Name:Sitagliptin
Percent  98%
EINECS/ELINCS
Hazard Symbols: Xi
Risk Phrases: 36/37/38

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. May cause irritating to eyes, respiratory system and skin

Potential Health Effects
Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion: May cause irritation of the digestive tract. Harmful if swallowed.
Inhalation: May be harmful if inhaled.
Chronic: No information found.

Section 4 - First Aid Measures 
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively

Section 5 - Fire Fighting Measures 
General Information: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - Accidental Release Measures 
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage 
Handling: Keep containers tightly sealed. Store in cool, dry place in tightly closed containers. Ensure good ventilation/exhaustion at the workplace.
Storage: No special requirements. Store away from oxidizing agents..

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes:Wear appropriate protective eyeglasses.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing:  Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties 
Physical State: Powder
Color: Off-white to white
Odor: Not available
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: No data available
Freezing/Melting Point: No data available
Autoignition Temperature: Not available
Flash Point: No data available
Decomposition Temperature:Not available.
Solubility: Not available
Specific Gravity/Density: Not determined
Molecular Formula: C16H15F6N5O

Molecular Weight: 407.32

Section 10 - Stability and Reactivity 
Chemical Stability: Stable. Incompatible with strong oxidizing agents, strong bases..
Conditions to Avoid: No decomposition if used and stored according to specifications..
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: has not been reported.

Section 11 - Toxicological Information 
RTECS#:   
CAS# 486460-32-6:
Carcinogenicity: Sitagliptin, 98% - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other Studies: The toxicological properties have not been fully investigated.

Section 12 - Ecological Information 
Additional ecological information:
General notes: no data available

Section 13 - Disposal Considerations
Recommendation: Consult state, local or national regulations for proper disposal. Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - Transport Information 
Shipping Name: Sitagliptin
UN Number: Not available
Packing Group: Not available
WGK Germany: Not available

Section 15 - Regulatory Information 
European Labeling in Accordance with EC Directives
      Hazard Class:Xi
      Risk Phrases:
             R 36/37/38 Irritating to eyes, respiratory system and skin
      Safety Phrases:
             Not available
Information about limitation of use: Employment restrictions concerning young persons must be observed. For use only by technically qualified individuals.
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Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.