Material Safety Data Sheet
PACLITAXEL,Taxol     

Section 1 - Chemical Product and Company Identification
MSDS Name: PACLITAXEL,Taxol
Catalog Numbers: SC-13778

Section 2 - Composition, Information on Ingredients 
CAS#33069-62-4
Chemical Name: PACLITAXEL,Taxol 
Percent  98%
EINECS/ELINCS: 205-285-7

Section 3 - Hazards Identification 
3.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
Respiratory sensitisation (Category 1), H334
Skin sensitisation (Category 1), H317
Germ cell mutagenicity (Category 2), H341
Reproductive toxicity (Category 2), H361
Specific target organ toxicity - single exposure (Category 2), H371
Specific target organ toxicity - single exposure (Category 3), H335
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn Harmful R20/21/22, R68/20/21/22
Xn Harmful R68
Xn Harmful R62
Xn Harmful R42/43
Xi Irritant R41, R37/38
For the full text of the R-phrases mentioned in this Section, see Section 16 
3.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram 
Signal word: Danger
Hazard statement(s)
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 May cause respiratory irritation.
H341 Suspected of causing genetic defects.
H361 Suspected of damaging fertility or the unborn child.
H371 May cause damage to organs.
Precautionary statement(s)
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Supplemental Hazard Statements: none
3.3 Other hazards - none

Section 4 - First Aid Measures 
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available

Section 5 - Fire Fighting Measures 
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available

Section 6 - Accidental Release Measures 
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

Section 7 - Handling and Storage 
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
7.3 Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

Section 8 - Exposure Controls, Personal Protection 
8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
 
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of  anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
 
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Section 9 - Physical and Chemical Properties 
Physical State: Powder
Color: White
Odor: Not available.
pH: 3.0 - 8.0 .
Vapor Pressure:
Viscosity: Not available.
Boiling Point: Not available
Freezing/Melting Point: 213 °C - dec.
Autoignition Temperature: Not available
Flash Point: Not available
Decomposition Temperature: Not available
Partition coefficient n-octanol/water: log Pow: > 99
Water Solubility: Not available
Specific Gravity/Density: 0,2 g/cm3
Molecular Formula: C47H51NO14
Molecular Weight: 853.91

Section 10 - Stability and Reactivity 
10.1 Reactivity: no data available
10.2 Chemical stability: Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions: no data available
10.4 Conditions to avoid: no data available
10.5 Incompatible materials: no data available
10.6 Hazardous decomposition products:
Other decomposition products - no data available
In the event of fire: see section 5
 

Section 11 - Toxicological Information 
11.1 Information on toxicological effects
Acute toxicity: no data available
Inhalation: no data available
Inhalation: Irritating to respiratory system.
Dermal: no data available
Skin corrosion/irritation: no data available
Serious eye damage/eye irritation: no data available 
Carcinogenicity:
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (2-Propanol)
Aspiration hazard: no data available
Additional Information
RTECS: DA8340700

Section 12 - Ecological Information 
12.1 Toxicity: no data available
12.2 Persistence and degradability: no data available
12.3 Bioaccumulative potential: no data available
12.4 Mobility in soil: no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects: no data available

Section 13 - Disposal Considerations 
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: -                                              IMDG: -                                              IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -                                              IMDG: -                                              IATA: -
14.4 Packaging group
ADR/RID: -                                              IMDG: -                                              IATA: -
14.5 Environmental hazards
ADR/RID: no                                           IMDG Marine pollutant: no                 IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information 
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

Section 16 - Additional Information
Full text of H-Statements referred to under sections 2 and 3.
Acute Tox. Acute toxicity
Eye Dam. Serious eye damage
Eye Irrit. Eye irritation
Flam. Liq. Flammable liquids
H225 Highly flammable liquid and vapour.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H319 Causes serious eye irritation.
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 May cause respiratory irritation.
H336 May cause drowsiness or dizziness.
H341 Suspected of causing genetic defects.
H361 Suspected of damaging fertility or the unborn child.
H370 Causes damage to organs.
H371 May cause damage to organs.
Muta. Germ cell mutagenicity
Repr. Reproductive toxicity
Resp. Sens. Respiratory sensitisation
Skin Irrit. Skin irritation
Skin Sens. Skin sensitisation
STOT SE Specific target organ toxicity - single exposure
Full text of R-phrases referred to under sections 2 and 3
F Highly flammable
R11 Highly flammable.
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
R36 Irritating to eyes.
R36/37 Irritating to eyes and respiratory system.
R37/38 Irritating to respiratory system and skin.
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with
skin and if swallowed.
T Toxic
Xi Irritant
R41 Risk of serious damage to eyes.
R42/43 May cause sensitisation by inhalation and skin contact.
R62 Possible risk of impaired fertility.
R67 Vapours may cause drowsiness and dizziness.
R68 Possible risk of irreversible effects.
R68/20/21/22 Harmful: possible risk of irreversible effects through inhalation, in contact with skin
and if swallowed.
Xn Harmful

While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.