Section 1 - Chemical Product and Company Identification
MSDS Name: Lycorine
Catalog Numbers: 86-40600
Section 2 - Composition, Information on Ingredients
CAS# 476-28-8
Chemical Name Lycorine
Percent 98%
EINECS/ELINCS: 207-503-6
Hazard Symbols: T
Risk Phrases: 25
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Potential Health Effects
Inhalation:Bronchospasm may develop in sensitized individuals.
Skin:Contact dermatitis is common. Eyes:Significant laryngeal and facial edema may occur. Breathing may be impaired as a result of laryngeal edema. Immediate (usually) or delayed hypersensitivity reactions have been described following application of PPD-containing hair dyes to eyebrows or eyelashes. Eye pain and burning, and edema occur, which may progress to widespread facial edema, dermatitis, tearing, photophobia, uveitis, and keratitis. Corneal necrosis and vision loss may occur. Bilateral optic neuritis has been reported with blindness.
Ingestion: Epigastric pain and recurrent vomiting are common shortly following ingestion.
Hazards:Contact with metals may evolve flammable hydrogen gas.
Section 4 - First Aid Measures
Ingestion: Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Eyes: Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Skin: Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Inhalation: Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Notes to Physician: Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information: When burning, it produces toxic fumes of nitrogen oxides, DOT recommendations-for small fires, use dry chemicals, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. If you can do it without risk, move containers from fire area.
Extinguishing Media: Use mist of water, carbon dioxide, sand, dry powder, foam.
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Section 7 - Handling and Storage
Handling: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Storage: Keep in a cool(2-8°C), dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear chemical splash goggles. Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective gloves, clothing and goggles.
Respirators: Wear positive pressure self-contained breathing apparatus (SCBA).
Section 9 - Physical and Chemical Properties
Physical State: White crystalline powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: not repored
Autoignition Temperature: Not available
Flash Point: Not avialable
Decomposition Temperature:Not available.
Solubility: Soluble in acid, insoluble in alcohol, chloroform and petroleum ether, almost insoluble in water and alkali
Specific Gravity/Density:.Not found
Molecular Formula:C16H17NO4
Molecular Weight: 287.31
Section 10 - Stability and Reactivity
Chemical Stability: A selective inhibitor of peptidyl transferase center (PTC).
Combustion products: Protect from light.
Section 11 - Toxicological Information
RTECS#:
CAS#476-28-8
LD50/LC50:
CAS# 476-28-8
acute toxicity : LD50 10700mg/kg (rat oral)
Rabbit Skin : 145mg/kg (24 hours), a mild irritant.
Carcinogenicity:
LYCORINE- Listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information found
Other Studies: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.
Section 12 - Ecological Information
a health hazard if swallowed.
Section 13 - Disposal Considerations
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - Transport Information
Shipping Name: Not regulated
Section 15 - Regulatory Information
Hazard Symbols: T
Risk Phrases:
R 25 Toxic if swallowed
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK (Water Danger/Protection)
CAS# 476-28-8 Germany 3
RIDADR UN 2811 6.1/PG 3
Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.
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