Material Safety Data Sheet
Gemcitabine   
Section 1 - Chemical Product and Company Identification
MSDS Name: Gemcitabine 
Catalog Numbers: 86-33681

Section 2 - Composition, Information on Ingredients 
CAS# 95058-81-4
Chemical Name: Gemcitabine   
Percent  98%
EINECS/ELINCS:Not available.
Hazard Symbols:Xn
Risk Phrases: 36/37/38-40-42/43

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Light sensitive.

Potential Health Effects
Inhalation: May be harmful if inhaled. Causes respiratory tract irritation.
Skin: May be harmful if absorbed through skin. Causes skin irritation.
Eyes: Causes serious eye irritation
Ingestion: May be harmful if swallowed.

Section 4 - First Aid Measures
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Section 6 - Accidental Release Measures 
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - Handling and Storage 
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Wash clothing before reuse.
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.

Personal Protective Equipment
Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin: Wear safety glasses and chemical goggles if splashing is possible.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - Physical and Chemical Properties 
Physical State: White
Color: crystalline powder
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.  
Viscosity: Not available.
Boiling Point: Not available. 
Melting point: 168,64 C
Autoignition Temperature: Not available
Flash Point: Not available.  
Explosion Limits: Lower: Not available
Explosion Limits: Upper: Not available
Decomposition Temperature: Not available. 
Specific Gravity/Density: Not available.

Molecular Formula: C9H11F2N3O4
Molecular Weight: 263.2

Section 10 - Stability and Reactivity 
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid:Incompatible materials, light.
Incompatibilities with Other Materials: Strong oxidizing agents, strong bases.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen iodide.
Hazardous Polymerization:Has not been reported.

Section 11 - Toxicological Information
RTECS#: Not available.
CAS#95058-81-4:  
LD50/LC50: RTECS: Not available.
Carcinogenicity:
Gemcitabine , 98%- Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other Studies: The toxicological properties have not been fully investigated.

Section 12 - Ecological Information 
Nor available

Section 13 - Disposal Considerations 
Dispose of in a manner consistent  with federal, state, and local regulations.

Section 14 - Transport Information 
Shipping Name: Not regulated

Section 15 - Regulatory Information 
European/International Regulations
      European Labeling in Accordance with EC Directives
           Hazard Symbols: Xn
           Risk Phrases:
                   R21: Harmful in contact with skin
                   R36/38: Irritating to eyes and skin
                   R46:May cause heritable genetic damage
                   R62:Possible risk of impaired fertility
                   R63:Possible risk of harm to the unborn child
           Safety Phrases:
                   S25: Avoid contact with eyes
                   S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
                   S36/37:Wear suitable protective clothing and gloves
                   S53:Avoid exposure - obtain special instruction before use                    
 
Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.