Material Safety Data Sheet
Bosentan hydrate 
 
Section 1 - Chemical Product and Company Identification
MSDS Name: Bosentan hydrate
Catalog Numbers: 86-38205

Section 2 - Composition, Information on Ingredients 
CAS#157212-55-0
Chemical Name:Bosentan hydrate
Percent  98%min
EINECS/ELINCS: Not available
Hazard Symbols: Not available
Risk Phrases: Not available

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. May cause irritation to eyes, respiratory system and skin.

Potential Health Effects
Eye: May cause serious eye irritation. The toxicological properties of this material have not been fully investigated.
Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation: Cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic: No information found.

Section 4 - First Aid Measures 
Eyes:Flush eyes with water as a precaution.
Skin: Wash off with soap and plenty of water.
Ingestion: Never give anything by mouth to an unconscious person. Rinse mouth with water.
Inhalation: If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Notes to Physician: Treat symptomatically and supportively

Section 5 - Fire Fighting Measures 
General Information: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self contained breathing apparatus for fire fighting if necessary.

Section 6 - Accidental Release Measures 
Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections: For disposal see section 13

Section 7 - Handling and Storage 
Precautions for safe handling: Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin: Wear safety chemical goggles if splashing is possible.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions

Section 9 - Physical and Chemical Properties 
Physical State: Powder
Color: Off-white
Odor: Not available
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
 Boiling Point: 742.3 °C at 760 mmHg
Freezing/Melting Point: Not available
Autoignition Temperature: Not available
 Flash Point: 402.8 °C
Decomposition Temperature: Not available.

Specific Gravity/Density: Not available.
Molecular Formula: C27H31N5O7S.
Molecular Weight: 569.62934.

Section 10 - Stability and Reactivity 
Chemical Stability: Not available.
Conditions to Avoid: Not available.
Incompatibilities with Other Materials: Oxidizing agents.
Hazardous Decomposition Products: carbon monoxide, carbon dioxide,hydrogen iodide.
Hazardous Polymerization: has not been reported.

Section 11 - Toxicological Information 
RTECS#: Not available.
CAS#157212-55-0
LD50/LC50: RTECS: Not available.
Carcinogenicity:
Bosentan hydrate ,98%min- Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other Studies: The toxicological properties have not been fully investigated.

Section 12 - Ecological Information 
Additional ecological information:
General notes: no data available

Section 13 - Disposal Considerations
Dispose of in a manner consistent  with federal, state, and local regulations.

Section 14 - Transport Information 
14.1 UN number
ADR/RID: -                     IMDG: -                                                  IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -                   IMDG: -                                                    IATA: -
14.4 Packaging group 
ADR/RID: -                   IMDG: -                                                     IATA: -
14.5 Environmental hazards
ADR/RID: no                IMDG Marine Pollutant: no                       IATA: no
14.6 Special precautions for user
no data available

Section 15 - Regulatory Information
European/International Regulations
      European Labeling in Accordance with EC Directives
           Hazard Symbols: Not available
           Risk Phrases:
                   Not reported
           Safety Phrases:
                  Not reported

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.